[Effect of plaferon in children treated for bronchial asthma].

Abstract

54 children with well-documented asthma (27 atopic and 27 nonatopic patients) were examined for peripherial blood serum immunoglobulins content in order to determine specific immunologic triggers of formation bronchial hyperreactivity, as well for their changes using inhaled method of treatment with Plaferon LB. According to the results of study, it was revealed statistically significant increase in G and M immunoglobulin concentrations and moderate decrease of E immunoglobulin content in atopic children. In contrast, Plaferon treatment of nonatopic children was associated in slight decrease of serum IgG concentration with simultaneous increase in IgA concentrations. These immunological changes are delineating the immunomodulatory activity of test drug.

• Authors: B Bezarashvili
• Journal: Georgian medical news (Georgian Med News) Issue 141 Pg. 53-6 (Dec 2006) ISSN: 1512-0112 [Print] Georgia (Republic)
• PMID: 17261888 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Asthmatic Agents
• Immunoglobulin G
• Neuropeptides
• plaferon
• Immunoglobulin E

Topics

• Administration, Inhalation
• Adolescent
• Anti-Asthmatic Agents (administration & dosage, pharmacology, therapeutic use)
• Asthma (drug therapy)
• Child
• Female
• Humans
• Immunoglobulin E (drug effects)
• Immunoglobulin G (drug effects)
• Male
• Neuropeptides (administration & dosage, pharmacology, therapeutic use)