[Clinical study of levonorgestrel-releasing intrauterine system for adenomyosis].

To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis.
Seventy patients with adenomyosis diagnosed according to clinical symptoms, magnetic resonance imaging (MRI) findings, laparoscopy and/or color-Doppler ultrasound imaging were treated with LNG-IUS, and the menstrual blood volume, dysmenorrhea, uterine volume, hepatic function and serum lipids were observed and evaluated.
In the first month of treatment, the menstrual blood size was reduced significantly to (35-/+12)% of that before treatment (P<0.01), and further to (7-/+4)% in the twelfth month (P<0.01). The average uterine volume was decreased by 18.6% (P<0.05) after the treatment, and dysmenorrhea was obviously relieved or completely disappeared alleviated. The condition of anemia was also improved rapidly, and no obvious side-effects on hepatic function and serum lipids were observed.
LNG-IUS is an effective and safe therapy for adenomyosis.
AuthorsShu-ming He, Yang-de Zhang
JournalNan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 26 Issue 12 Pg. 1794-6 (Dec 2006) ISSN: 1673-4254 [Print] China
PMID17259122 (Publication Type: Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Contraceptive Agents, Female
  • Levonorgestrel
  • Adult
  • Contraceptive Agents, Female (administration & dosage, therapeutic use)
  • Endometriosis (drug therapy, pathology)
  • Female
  • Follow-Up Studies
  • Humans
  • Intrauterine Devices, Medicated
  • Levonorgestrel (administration & dosage, therapeutic use)
  • Treatment Outcome

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