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[Clinical study of levonorgestrel-releasing intrauterine system for adenomyosis].

AbstractOBJECTIVE:
To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis.
METHODS:
Seventy patients with adenomyosis diagnosed according to clinical symptoms, magnetic resonance imaging (MRI) findings, laparoscopy and/or color-Doppler ultrasound imaging were treated with LNG-IUS, and the menstrual blood volume, dysmenorrhea, uterine volume, hepatic function and serum lipids were observed and evaluated.
RESULTS:
In the first month of treatment, the menstrual blood size was reduced significantly to (35-/+12)% of that before treatment (P<0.01), and further to (7-/+4)% in the twelfth month (P<0.01). The average uterine volume was decreased by 18.6% (P<0.05) after the treatment, and dysmenorrhea was obviously relieved or completely disappeared alleviated. The condition of anemia was also improved rapidly, and no obvious side-effects on hepatic function and serum lipids were observed.
CONCLUSION:
LNG-IUS is an effective and safe therapy for adenomyosis.
AuthorsShu-ming He, Yang-de Zhang
JournalNan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 26 Issue 12 Pg. 1794-6 (Dec 2006) ISSN: 1673-4254 [Print] China
PMID17259122 (Publication Type: Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Contraceptive Agents, Female
  • Levonorgestrel
Topics
  • Adult
  • Contraceptive Agents, Female (administration & dosage, therapeutic use)
  • Endometriosis (drug therapy, pathology)
  • Female
  • Follow-Up Studies
  • Humans
  • Intrauterine Devices, Medicated
  • Levonorgestrel (administration & dosage, therapeutic use)
  • Treatment Outcome

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