Cytomegalovirus retinitis after fluocinolone acetonide (Retisert) implant.

Abstract

PURPOSE:

To report a case of cytomegalovirus (CMV) retinitis after placement of a fluocinolone acetonide (Retisert) implant.

DESIGN:

Interventional case report.

METHODS:

Retrospective chart review.

RESULTS:

A 65-year-old man with a history of Adamantiades-Behcet disease and bilateral recurrent uveitis that was unresponsive to systemic corticosteroid-sparing immunosuppressive therapy developed clinical evidence of CMV retinitis after receiving his second intravitreal Retisert implant in the left eye, while on no systemic immunosuppression. He did not develop CMV retinitis in the right eye despite multiple intraocular and periocular steroid injections. The patient responded well to intravitreal foscarnet followed by placement of an intravitreal ganciclovir implant.

CONCLUSIONS:

Ophthalmologists should be aware of the potential risk for development of CMV retinitis after local ocular immunosuppressive therapy.

• Authors: Rafael L Ufret-Vincenty, Rishi P Singh, Careen Y Lowder, Peter K Kaiser
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 143 Issue 2 Pg. 334-5 (Feb 2007) ISSN: 0002-9394 [Print] United States
• PMID: 17258523 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiviral Agents
• Drug Implants
• Glucocorticoids
• Fluocinolone Acetonide
• Foscarnet
• Ganciclovir

Topics

• Aged
• Antiviral Agents (therapeutic use)
• Behcet Syndrome (complications)
• Cytomegalovirus Retinitis (diagnosis, drug therapy, etiology)
• Drug Implants
• Fluocinolone Acetonide (administration & dosage, adverse effects)
• Foscarnet (therapeutic use)
• Ganciclovir (therapeutic use)
• Glucocorticoids (administration & dosage, adverse effects)
• Humans
• Immunocompromised Host
• Macular Edema (drug therapy)
• Male
• Retrospective Studies
• Uveitis (complications)