[The extracorporeal immunostimulating effect of terrilytin in staphylococcal infection].

Abstract	The intravenous injection of terrilytin-treated lymphocytes into rats infected with staphylococci enhances the formation of staphylococcal alpha antitoxin in the animals and the development of immune response to T-dependent antigen, such as sheep red blood cells (SRBC), but produces no effect on the development of immune response induced by T-independent antigen (lipopolysaccharide). Terrilytin-treated lymphocytes induce the release of the factor promoting the development of immune response to staphylococcal antigens and SRBC by spleen cells, incapable of adherence to plastic, but have no influence on the development of immune response to lipopolysaccharide in rats infected with staphylococci. At the same time in such rats spleen cells adhering to plastic take part in the transfer of signals from terrilytin-treated lymphocytes to nonadhering spleen cells of recipients.
Authors	L G Prokopenko, N A Bystrova
Journal	Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 11 Pg. 53-6 (Nov 1991) ISSN: 0372-9311 [Print] Russia (Federation)
Vernacular Title	Ekstrakorporal'nyĭ immunostimuliruiushchiĭ éffekt terrilitina pri stafilokokkovoĭ infektsii.
PMID	1725838 (Publication Type: English Abstract, Journal Article)
Chemical References	Adjuvants, Immunologic Antitoxins Bacterial Toxins Drug Combinations Hemolysin Proteins staphylococcal alpha-toxin amylase, phosphates, proteases drug combinations Amylases Peptide Hydrolases
Topics	Adjuvants, Immunologic (therapeutic use) Amylases (therapeutic use) Animals Antitoxins (blood, drug effects) Bacterial Toxins (immunology) Cell Adhesion (drug effects, immunology) Cell Separation Drug Combinations Drug Evaluation, Preclinical Hemolysin Proteins (immunology) Lymphocyte Activation (drug effects, immunology) Lymphocyte Transfusion Lymphocytes (drug effects, immunology) Peptide Hydrolases (therapeutic use) Rats Rats, Inbred Strains Spleen (cytology, immunology) Staphylococcal Infections (immunology, therapy)

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