5-Hydroxytryptamine is emetogenic in the house musk shrew, Suncus murinus.

Abstract

The emetic effects of 5-hydroxytryptamine (5-HT) and 5-HT3 receptor agonists were investigated in the house musk shrew, Suncus murinus. 5-Hydroxytryptamine (5-HT; i.p., i.v., s.c.) and 2-methyl-5-HT (2-Me-5-HT; i.p.) but not 5-hydroxyindoleacetic acid (i.p.) or 5-methoxytryptamine (i.p.) induced emesis with very short latency. Tropisetron (ICS 205-930, a 5-HT3 receptor antagonist, s.c.) blocked the emesis induced by 5-HT (10 mg/kg, i.p.) and 2-Me-5-HT (5 mg/kg, i.p.) with respective ID50 values of 7.8 and 70.9 micrograms/kg. Pindolol (5-HT1 receptor antagonist) and ketanserin (5-HT2 receptor antagonist) were about 100 times less potent than tropisetron. The emesis induced by 5-HT was prevented by surgical vagotomy but not by pretreatment with a combination of atropine (0.1 mg/kg, s.c.) and hexamethonium (10 mg/kg, s.c.). These results clearly indicate that 5-HT is emetogenic probably through a stimulation of peripheral 5-HT3 receptors.

• Authors: Y Torii, H Saito, N Matsuki
• Journal: Naunyn-Schmiedeberg's archives of pharmacology (Naunyn Schmiedebergs Arch Pharmacol) Vol. 344 Issue 5 Pg. 564-7 (Nov 1991) ISSN: 0028-1298 [Print] Germany
• PMID: 1725807 (Publication Type: Journal Article)

Chemical References

• Receptors, Serotonin
• Serotonin Antagonists
• Serotonin
• 5-Methoxytryptamine
• Hydroxyindoleacetic Acid

Topics

• 5-Methoxytryptamine (toxicity)
• Animals
• Female
• Hydroxyindoleacetic Acid (toxicity)
• Injections, Intraperitoneal
• Injections, Intravenous
• Injections, Subcutaneous
• Male
• Receptors, Serotonin (drug effects)
• Serotonin (administration & dosage, toxicity)
• Serotonin Antagonists (pharmacology)
• Shrews
• Vagotomy
• Vomiting (chemically induced)