Abstract | BACKGROUND: Post-operative ischemia after coronary artery bypass grafting (CABG) is well described but effective intervention requires immediate diagnosis. One possible way of increasing efficacy of peri-operative myocardial monitoring is using the microdialysis technique. METHODS: In 30 patients undergoing routine CABG, a microdialysis catheter was inserted in the left heart in an area of abnormal ventricular contraction. A second catheter was placed in normal tissue of the right ventricle. Microdialysis measurements were performed at time intervals before, during and 24 h after cardiopulmonary bypass (CPB) and retrospectively compared with standard clinical monitoring and clinical course. RESULTS: During CPB, both ventricles showed signs of poor tissue oxygenation. Glycerol was significantly higher in the left myocardium (146 +/- 67 vs. 72 +/- 36 micromol/l) and the glucose/ lactate ratio (GLR), as a marker of nutritional disorder of the right ventricle (41 +/- 15% vs. 67 +/- 17%, P < 0.05), had significantly better values at this time point. Myocardial lactate concentrations were significantly higher in the dyskinetic segments (2.82 +/- 0.81 vs. 1.5 +/- 0.81 microM). During this period, no abnormal clinical standard monitoring results were observed. Post-operative significantly increased lactate/ pyruvate ratios of three patients were clinically associated with peri-operative myocardial infarction (108 +/- 67 vs. 38 +/- 9, P < 0.05). The lactate/ pyruvate ratio started rising before any other standard monitoring tools showed abnormal values. CONCLUSIONS: Peri-operative microdialytic measurements of parameters related to ischemia can be safely performed in a clinical setting, resulting in faster and more reliable detection of ongoing or new ischemia.
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Authors | J Pöling, W Rees, S Klaus, L Bahlmann, N Hübner, V Mantovani, H Warnecke |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 51
Issue 3
Pg. 341-6
(Mar 2007)
ISSN: 0001-5172 [Print] England |
PMID | 17257174
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Blood Glucose
- Lactic Acid
- Glycerol
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Topics |
- Aged
- Analysis of Variance
- Biomarkers
(blood)
- Blood Glucose
(analysis)
- Coronary Artery Bypass
(adverse effects)
- Glycerol
(blood)
- Humans
- Lactic Acid
(blood)
- Microdialysis
(instrumentation, methods)
- Middle Aged
- Myocardial Ischemia
(diagnosis, etiology)
- Myocardium
(metabolism)
- Postoperative Period
- Retrospective Studies
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