Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J.

Abstract	A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
Authors	Maurizio Botta, Silvia Armaroli, Daniele Castagnolo, Gabriele Fontana, Paula Pera, Ezio Bombardelli
Journal	Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 17 Issue 6 Pg. 1579-83 (Mar 15 2007) ISSN: 0960-894X [Print] England
PMID	17254787 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	2-deacetoxytaxinine J Antineoplastic Agents, Phytogenic Indicators and Reagents Taxoids
Topics	Antineoplastic Agents, Phytogenic (chemical synthesis, pharmacology) Breast Neoplasms (drug therapy, pathology) Cell Line, Tumor Drug Resistance, Neoplasm Female Genes, MDR (genetics) Humans Indicators and Reagents Taxoids (chemical synthesis, pharmacology)

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