Antioxidants and CVD in diabetes: where do we stand now.

Abstract

Diabetes is an oxidative stress disorder as a result of both hyperglycemia and increased levels of free fatty acids. Oxidative stress has been implicated in the pathogenesis of diabetes-related complications, and treatment with antioxidants seemed to be a promising therapeutic option. Although animal studies and preliminary human studies were initially encouraging, subsequent human studies have failed to show a clear benefit of antioxidants, whereas some studies have even suggested that they can be potentially harmful. Therefore, treatment with antioxidants cannot be currently recommended as a therapeutic option.

• Authors: Susie Yim, Atul Malhotra, Aristidis Veves
• Journal: Current diabetes reports (Curr Diab Rep) Vol. 7 Issue 1 Pg. 8-13 (Feb 2007) ISSN: 1534-4827 [Print] United States
• PMID: 17254512 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Antioxidants

Topics

• Animals
• Antioxidants (adverse effects, pharmacology, therapeutic use)
• Cardiovascular Diseases (complications, drug therapy, metabolism)
• Diabetes Mellitus (drug therapy, metabolism)
• Diet
• Endothelium (drug effects, metabolism, physiopathology)
• Humans
• Oxidative Stress