rho-Associated Kinases

A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT CHAIN PHOSPHATASE and LIM KINASES.

Also Known As:

ROCK Protein Kinases; ROCK-I Protein Kinase; ROCK-II Protein Kinase; ROK Kinase; p160 rhoA-Binding Kinase ROKalpha; p160ROCK; rho-Associated Coiled-Coil Containing Protein Kinase 1; rho-Associated Coiled-Coil Containing Protein Kinase 2; rho-Associated Coiled-Coil Kinase; rho-Associated Kinase 1; rho-Associated Kinase 2; rho-Associated Kinase alpha; rho-Associated Kinase beta; rho-Associated Protein Kinase alpha; rho-Associated Protein Kinase beta; rho-Kinase; Coiled-Coil Kinase, rho-Associated; Protein Kinases, ROCK; ROCK I Protein Kinase; ROCK II Protein Kinase; p160 rhoA Binding Kinase ROKalpha; rho Associated Coiled Coil Containing Protein Kinase 1; rho Associated Coiled Coil Containing Protein Kinase 2; rho Associated Coiled Coil Kinase; rho Associated Kinase; rho Associated Kinase 1; rho Associated Kinase 2; rho Associated Kinase alpha; rho Associated Kinase beta; rho Associated Kinases; rho Associated Protein Kinase alpha; rho Associated Protein Kinase beta; rho Kinase; rho-Associated Kinase

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Enzymes and Coenzymes: 1

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Enzymes: 24507

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Transferases: 3187

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Phosphotransferases: 15123

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Phosphotransferases (Alcohol Group Acceptor)

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Protein Kinases: 5355

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Protein-Serine-Threonine Kinases: 677

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rho-Associated Kinases: 563

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Amino Acids, Peptides, and Proteins

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Proteins: 57092

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Intracellular Signaling Peptides and Proteins: 16

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rho-Associated Kinases: 563

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Peptides: 16194

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Intracellular Signaling Peptides and Proteins: 16

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rho-Associated Kinases: 563

Authors	Xing-zhen Sun, Da-wei Wang, Jun Li
Journal	Zhonghua er ke za zhi. Chinese journal of pediatrics (Zhonghua Er Ke Za Zhi) Vol. 44 Issue 12 Pg. 946-7 (Dec 2006) ISSN: 0578-1310 China
PMID	17254468 (Publication Type: Journal Article)

[Effects of intervention with Rho kinase inhibitor fasudil on rats with hypoxic pulmonary hypertension]