| Abstract | The list of shock mediators currently comprises more than 150 candidates. A careful analysis using the criteria of Koch-Dale together with decision trees for exclusion of bias revealed that only histamine, C5a, beta-endorphin, tumor necrosis factor (TNF) thromboxane B2, platelet-activating factor (PAF), and oxygen free radicals are shown to be causally associated with shock symptoms. Although experimental studies with inhibitors of these mediators were convincing, there is still a lack of evidence under clinical conditions (exception histamine: anaphylactic shock). Combinations of antagonists against different causal mediators are the most promising future approaches. |
| Authors | E Neugebauer, A Leuchleuthner, A Dietrich, S Saad, D Rixen
(Affiliation: Biochemische und Experimentelle Abteilung, Universität zu Köln, Bundesrepublik Deutschland.)
|
| Journal | Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress
(Langenbecks Arch Chir Suppl Kongressbd)
Pg. 309-18
( 1991)
ISSN: 0942-2854 GERMANY |
| Vernacular Title | Mediatoren und ihre Antagonisten in der Schocktherapie. |
| PMID | 1724395
(Publication Type: English Abstract, Journal Article, Review)
|
| Chemical References |
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| Topics |
- Acute-Phase Proteins
(physiology)
- Acute-Phase Reaction
(physiopathology, therapy)
- Critical Care
(methods)
- Humans
- Shock, Surgical
(physiopathology, therapy)
|
