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Comparison of the effects of four hyperplastic agents on hamster cheek pouch mucosa.

Abstract
Hyperplasia in the hamster cheek pouch was examined using 4 different hyperplastic agents: oil of turpentine 50% v/v in liquid paraffin; vitamin A palmitate 10% w/v in liquid paraffin; 12-O-tetradeconyl-phorbol-13-acetate 16nM in acetone; and ethylphenylpropiolate 0.04mM in acetone. Acetone, paraffin and untreated control groups were also examined. Cheek pouches were painted 3 times a week for up to 4 weeks with each solution. Samples were removed and prepared for light microscopy 24 hours after 2 weeks of painting and 24 hours, 6, 12 and 18 weeks after 4 weeks of painting. Hyperplasia was produced by application of turpentine, vitamin A and TPA after 2 weeks of application. Further increases in epithelial width occurred after 4 weeks of painting in the turpentine and vitamin A groups but a decrease was seen in the TPA group. Six weeks (vitamin A and TPA groups) or 12 weeks (turpentine group) after the completion of treatment the epithelium had a normal histological appearance. No differences between the control or EPP treated cheek pouch mucosa could be detected. Turpentine and vitamin A can be used as models of reversible hyperplasia in the hamster cheek pouch.
AuthorsB H Shearer, M D McMillan, H F Jenkinson
JournalJournal de biologie buccale (J Biol Buccale) Vol. 19 Issue 4 Pg. 315-8 (Dec 1991) ISSN: 0301-3952 [Print] France
PMID1724238 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Alkynes
  • Diterpenes
  • Retinyl Esters
  • keratohyalin
  • Vitamin A
  • retinol palmitate
  • ethylphenylpropiolate
  • Keratins
  • Tetradecanoylphorbol Acetate
  • Turpentine
Topics
  • Alkynes (pharmacology)
  • Animals
  • Cell Nucleus (drug effects, ultrastructure)
  • Connective Tissue (drug effects, pathology)
  • Cricetinae
  • Cytoplasmic Granules (ultrastructure)
  • Diterpenes
  • Epithelium (drug effects, pathology)
  • Hyalin
  • Hyperplasia
  • Keratins
  • Male
  • Mouth Mucosa (drug effects, pathology)
  • Retinyl Esters
  • Tetradecanoylphorbol Acetate (pharmacology)
  • Time Factors
  • Turpentine (pharmacology)
  • Vitamin A (analogs & derivatives, pharmacology)

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