Fulminant amoebic colitis following loperamide use.

Abstract	Toxic megacolon is a rare consequence of infection with Entamoeba histolytica. We present such a patient in whom the course of disease may have been influenced by heavy loperamide use. Loperamide and other anti-motility agents have been implicated previously in the pathogenesis of toxic megacolon in patients with infectious gastroenteritis.
Authors	Alastair McGregor, Michael Brown, Khin Thway, Stephen G Wright
Journal	Journal of travel medicine (J Travel Med) 2007 Jan-Feb Vol. 14 Issue 1 Pg. 61-2 ISSN: 1195-1982 [Print] England
PMID	17241255 (Publication Type: Case Reports, Journal Article)
Chemical References	Antidiarrheals Loperamide
Topics	Animals Antidiarrheals (administration & dosage, adverse effects) Colectomy Diagnosis, Differential Diarrhea (drug therapy, pathology) Dysentery, Amebic (diagnosis, pathology, surgery) Entamoeba histolytica (isolation & purification) Female Humans Loperamide (administration & dosage, adverse effects) Middle Aged Severity of Illness Index Travel

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