| Abstract | BACKGROUND: This study investigated whether brief exposure to nitrous oxide (N(2)O) exacerbates levodopa-induced hyperhomocysteinemia, and if co-treatment with folate or entacapone could reduce total plasma homocysteine (tHcy) levels. METHODS: MALE WISTAR RATS (N=9 PER GROUP) WERE RANDOMLY TREATED WITH VEHICLE/N(2)O (GROUP 1), levodopa/nitrogen (group 2), levodopa/N(2)O (group 3), levodopa/N(2)O+folate (group 4), or levodopa/N(2)O+entacapone (group 5). tHcy was measured at 12 min, 4, 8, and 12 h after anesthesia. Results and conclusion: The combination of N(2)O-exposure and levodopa treatment significantly increased tHcy in rats. This hyperhomocysteinemia could be prevented by entacapone but not folate co-administration. |
| Authors | Nils Henninger, Qi Wang, Jürgen G Okun, Stefan Schwab, Martin Krause
(Affiliation: Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Nils.Henninger at umassmed.edu)
|
| Journal | Parkinsonism & related disorders
(Parkinsonism Relat Disord)
Vol. 13
Issue 8
Pg. 524-7
(Dec 2007)
ISSN: 1353-8020 England |
| PMID | 17240187
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Analgesics, Non-Narcotic
- Catechols
- Enzyme Inhibitors
- Levodopa
- Nitriles
- Nitrous Oxide
- entacapone
- Homocysteine
|
| Topics |
- Analgesics, Non-Narcotic
(pharmacology)
- Analysis of Variance
- Animals
- Catechols
(pharmacology)
- Drug Interactions
- Enzyme Inhibitors
(pharmacology)
- Homocysteine
(blood)
- Hyperhomocysteinemia
(blood, chemically induced)
- Immunoassay
(methods)
- Levodopa
- Male
- Nitriles
(pharmacology)
- Nitrous Oxide
(pharmacology)
- Random Allocation
- Rats
- Rats, Wistar
|
