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Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits.

Abstract
Previously, we reported that a relatively selective adenosine A(2A) receptor agonist 2-(6-cyano-1-hexyn-1-yl)adenosine (2-CN-Ado) elicited ocular hypotension in rabbits (Journal of Pharmacological Sciences 2005;97:501-509). In the present study, we investigated the effect of 2-CN-Ado on ocular blood flow in rabbit eyes. An intravitreal injection of 2-CN-Ado increased ocular blood flow, measured by a non-contact laser flowmeter. 2-CN-Ado-induced increase in ocular blood flow was accompanied with the retinal vasodilation. The increase in ocular blood flow was inhibited by an adenosine A(2A) receptor antagonist 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine, but not by an adenosine A(2B) receptor antagonist alloxazine or an adenosine A(1) receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine. The repetitive applications of topical 2-CN-Ado twice a day for 7 days produced a persistent increase in ocular blood flow with ocular hypotension. These results suggest that 2-CN-Ado increases the ocular blood flow mainly via adenosine A(2A) receptor, and that the topical application of 2-CN-Ado for several days not only increases the ocular blood flow but also prolong ocular hypotension, indicating that 2-CN-Ado may be a useful lead compound for the treatment of ischemic retinal diseases such as glaucoma.
AuthorsTakashi Konno, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Norimichi Nakahata
JournalLife sciences (Life Sci) Vol. 80 Issue 12 Pg. 1115-22 (Feb 27 2007) ISSN: 0024-3205 [Print] Netherlands
PMID17239401 (Publication Type: Journal Article)
Chemical References
  • 2-(6-cyano-1-hexyn-1-yl)adenosine
  • Adenosine A1 Receptor Antagonists
  • Adenosine A2 Receptor Antagonists
  • Flavins
  • Vasodilator Agents
  • Xanthines
  • 8-(3-chlorostyryl)caffeine
  • Caffeine
  • isoalloxazine
  • 1,3-dipropyl-8-cyclopentylxanthine
  • Adenosine
Topics
  • Adenosine (administration & dosage, adverse effects, analogs & derivatives, pharmacology)
  • Adenosine A1 Receptor Antagonists
  • Adenosine A2 Receptor Antagonists
  • Animals
  • Caffeine (analogs & derivatives, pharmacology)
  • Eye (blood supply, metabolism)
  • Flavins (pharmacology)
  • Intraocular Pressure (drug effects)
  • Male
  • Rabbits
  • Regional Blood Flow (drug effects)
  • Retinal Vessels (drug effects, metabolism)
  • Vasodilator Agents (administration & dosage, pharmacology)
  • Xanthines (pharmacology)

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