| Abstract | A patient with multiple myeloma (MM) was being maintained on human recombinant interferon-alpha (INF-alpha) after VAD and autologous bone marrow transplantation (pretreated with melphalan). An episode of immune thrombocytopenia and (Coombs positive) autoimmune hemolytic anemia (AIHA) was noted while on maintenance INF-alpha, which remitted when it was withdrawn. Following this event, he achieved a state of stable disease that persists (more than 3 years) with no specific myeloma treatment. This sequence of events suggests a relationship between an immunological reaction induced by INF-alpha and the prolonged phase of stable disease. |
| Authors | Benjamin Gesundheit, Orly Zelig, Michael Y Shapira, Aliza Ackerstein, Meytal Avgil, Reuven Or
(Affiliation: Department of Bone Marrow Transplantation, Cancer Immunotherapy and Immunobiology Research Center, Hadassah University Hospital, Jerusalem, Israel. gesund at hadassah.org.il)
|
| Journal | American journal of hematology
(Am J Hematol)
Vol. 82
Issue 6
Pg. 489-92
(Jun 2007)
ISSN: 0361-8609 United States |
| PMID | 17236186
(Publication Type: Case Reports, Journal Article)
|
| Copyright | (c) 2007 Wiley-Liss, Inc. |
| Chemical References |
- Interferon Type I, Recombinant
|
| Topics |
- Anemia, Hemolytic, Autoimmune
(diagnosis, immunology, therapy)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bone Marrow Transplantation
(methods)
- Follow-Up Studies
- Humans
- Interferon Type I, Recombinant
(therapeutic use)
- Male
- Middle Aged
- Multiple Myeloma
(diagnosis, immunology, therapy)
- Purpura, Thrombocytopenic, Idiopathic
(diagnosis, immunology, therapy)
- Remission Induction
- Transplantation, Autologous
- Treatment Outcome
|
