[Successful treatment of intrapericardial administration of carboplatin following systemic chemotherapy in a case of advanced thymic cancer with cardiac tamponade].

Abstract

A 72-year-old woman developed cardiac tamponade due to direct invasion of thymic cancer. Carboplatin was administered into the pericardial cavity two times with a total dose of 600 mg. Pericardial effusion disappeared without any toxicities. Following four cycles of systemic chemotherapy by carboplatin, doxorubicin, vincristine, cyclophosphamide (ADOC), partial response was obtained. She is alive 10 month after being given a diagnosis of cardiac tamponade. Intrapericardial administration of carboplatin is a useful therapy for control of pericardial effusion and chemosensitive cases should de identified among patients with thymic cancer.

• Authors: Mitsuyo Okada, Tomonobu Koizumi, Masanori Yasuo, Kenji Tsushima, Kazuhisa Urushihata, Shinji Yamaguchi, Masayuki Hanaoka, Keisaku Fujimoto, Keishi Kubo
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 44 Issue 12 Pg. 968-72 (Dec 2006) ISSN: 1343-3490 [Print] Japan
• PMID: 17233396 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Vincristine
• Doxorubicin
• Cyclophosphamide
• Carboplatin
• Cisplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carboplatin (administration & dosage)
• Carcinoma, Squamous Cell (drug therapy, secondary)
• Cardiac Tamponade (drug therapy, etiology)
• Cisplatin (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Female
• Humans
• Liver Neoplasms (secondary)
• Pleural Effusion, Malignant (drug therapy, etiology)
• Remission Induction
• Thymus Neoplasms (drug therapy, pathology)
• Vincristine (administration & dosage)