Analysis of anti-protective antigen IgG subclass distribution in recipients of anthrax vaccine adsorbed (AVA) and patients with cutaneous and inhalation anthrax.

• Abstract: The anti-PA IgG1, IgG2, IgG3, and IgG4 subclass responses to clinical anthrax and to different numbers of anthrax vaccine adsorbed (AVA, BioThrax) injections were determined in a cross-sectional study of sera from 63 vaccinees and 13 clinical anthrax patients. The data show that both vaccination with three AVA injections and clinical anthrax elicit anti-PA IgG1, IgG2, and IgG3 subclass responses. An anti-PA IgG4 response was detected in AVA recipients after the fourth injection. The anthrax lethal toxin (LTx) neutralization efficacy of sera from recipients who received 4 to > or =10 AVA injections did not vary significantly in relation to changes in distribution of anti-PA IgG1 and IgG4 subclasses.
• Authors: V A Semenova, D S Schmidt, T H Taylor Jr, H Li, E Steward-Clark, S D Soroka, M M Ballard, C P Quinn (Affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. vsemenova at cdc.gov)
• Journal: Vaccine (Vaccine) Vol. 25 Issue 10 Pg. 1780-8 (Feb 26 2007) ISSN: 0264-410X [Print] Netherlands
• PMID: 17229495 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anthrax Vaccines
• Antibodies, Bacterial
• Antigens, Bacterial
• Antitoxins
• Bacterial Toxins
• Immunoglobulin G
• anthrax toxin

Topics

• Adult
• Aged
• Anthrax (immunology)
• Anthrax Vaccines (immunology)
• Antibodies, Bacterial (blood, classification)
• Antigens, Bacterial (immunology)
• Antitoxins (blood)
• Bacterial Toxins (immunology)
• Female
• Humans
• Immunoglobulin G (blood, classification)
• Male
• Middle Aged