| Abstract | For making use of Ginseng resources and finding new anti-tumor drugs, the anti-tumor activity of three kinds of new panaxadiol fatty acid ester derivates: 3beta-acetoxy panaxadiol (I), 3beta-palmitic acid aceloxy panaxadiol (II), 3beta-octadecanoic acid aceloxy panaxadiol (Ill) and panaxaiol were compared through the method of cell stain and counting. Tumor cell was Vero cell line. Positive control was 5-FU. Blank was RPM11640 culture medium. Negative control was RPM11640 culture medium and the solvent for subjected drugs. The result showed that compound I had the strongest anti-tumor activity, second was panaxadiol, II and III had the same and the weakest antitumor activity. Furthermore, the anti-tumor activities of panaxadiol fatty acid ester derivates showed positive correlation with subjects' concentrations, but no relationship with molecular weight of fatty acid. |
| Authors | Chun-Hong Zhang, Lian-Xue Zhang, Xiang-Gao Li, Yu-Gang Gao, Ya-Jing Liu
(Affiliation: Academy of Chinese Traditional Medicine, Jilin Agricultural University, Changchun 130118, China. zchlhh at tom.com)
|
| Journal | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
(Zhong Yao Cai)
Vol. 29
Issue 11
Pg. 1200-3
(Nov 2006)
ISSN: 1001-4454 China |
| PMID | 17228662
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antineoplastic Agents, Phytogenic
- Drugs, Chinese Herbal
- Esters
- Fatty Acids
- Ginsenosides
- Triterpenes
- panaxadiol
|
| Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Cell Count
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cercopithecus aethiops
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Drugs, Chinese Herbal
(administration & dosage, pharmacology)
- Esters
(administration & dosage, pharmacology)
- Fatty Acids
(administration & dosage, pharmacology)
- Ginsenosides
(administration & dosage, pharmacology)
- Panax
(chemistry)
- Plants, Medicinal
(chemistry)
- Triterpenes
(administration & dosage, pharmacology)
- Vero Cells
|
