| Abstract | The 5-HT(2C) receptor subtype has been implicated in a wide variety of conditions including obesity, anxiety, depression, obsessive compulsive disorder, schizophrenia, migraine and erectile dysfunction and as a consequence has received considerable attention as a target for drug discovery. Here we review the pharmacological, pharmacokinetic and toxicological profile of WAY-163909 {(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole}, a novel 5-HT(2C) receptor selective agonist. Consistent with a potential therapeutic utility in obesity, schizophrenia and depression WAY-163909 was found to have robust dose-dependent effects in animal models of obesity, psychotic-like behavior or depression. |
| Authors | John Dunlop, Karen L Marquis, H K Lim, Louis Leung, John Kao, Cynthia Cheesman, Sharon Rosenzweig-Lipson
(Affiliation: Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543, USA. dunlopj at wyeth.com)
|
| Journal | CNS drug reviews
(CNS Drug Rev)
2006 Fall-Winter
Vol. 12
Issue 3-4
Pg. 167-77
ISSN: 1080-563X United States |
| PMID | 17227285
(Publication Type: Evaluation Studies, Journal Article, Review)
|
| Chemical References |
- 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole
- Antidepressive Agents
- Antipsychotic Agents
- Azepines
- Indoles
- Receptor, Serotonin, 5-HT2C
|
| Topics |
- Animals
- Antidepressive Agents
(pharmacology, therapeutic use)
- Antipsychotic Agents
(chemistry, pharmacology, therapeutic use)
- Azepines
(chemistry, metabolism, pharmacology, therapeutic use)
- Eating
(drug effects)
- Humans
- Indoles
(chemistry, metabolism, pharmacology, therapeutic use)
- Receptor, Serotonin, 5-HT2C
(agonists)
|
