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Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine.

Abstract
Pancreatitis-associated protein (PAP) was discovered in the pancreatic juice of rats with acute pancreatitis. PAP is a 16 kDa secretory protein structurally related to the C-type lectins although classical lectin-related function has not been reported yet. Then, it was demonstrated that PAP expression may be activated in some tissues in a constitutive or injury- and inflammation-induced manner. More recently, it has been found that PAP acts as an anti-inflammatory factor in vitro and in vivo. PAP expression can be induced by several pro- and anti-inflammatory cytokines and by itself through a JAK/STAT3-dependent pathway. PAP is able to activate the expression of the anti-inflammatory factor SOCS3 through the JAK/STAT3-dependent pathway. The JAK/STAT3/SOCS3 pathway seems to be a common point between PAP and several cytokines. Therefore, it is reasonable to propose that PAP is a new anti-inflammatory cytokine.
AuthorsDaniel Closa, Yoshiharu Motoo, Juan L Iovanna
JournalWorld journal of gastroenterology (World J Gastroenterol) Vol. 13 Issue 2 Pg. 170-4 (Jan 14 2007) ISSN: 1007-9327 [Print] United States
PMID17226896 (Publication Type: Editorial, Review)
Chemical References
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Cytokines
  • Inflammation Mediators
  • Lectins
  • Lectins, C-Type
  • Pancreatitis-Associated Proteins
  • REG3A protein, human
  • Reg3b protein, rat
  • STAT3 Transcription Factor
Topics
  • Animals
  • Antigens, Neoplasm (chemistry, isolation & purification, metabolism)
  • Biomarkers, Tumor (chemistry, isolation & purification, metabolism)
  • Cytokines (chemistry, isolation & purification, metabolism)
  • Inflammation Mediators (chemistry, isolation & purification, metabolism)
  • Lectins (chemistry)
  • Lectins, C-Type (chemistry, isolation & purification, metabolism)
  • Pancreatitis (genetics, metabolism)
  • Pancreatitis-Associated Proteins
  • Rats
  • STAT3 Transcription Factor (metabolism)

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