Abstract |
Pancreatitis-associated protein (PAP) was discovered in the pancreatic juice of rats with acute pancreatitis. PAP is a 16 kDa secretory protein structurally related to the C-type lectins although classical lectin-related function has not been reported yet. Then, it was demonstrated that PAP expression may be activated in some tissues in a constitutive or injury- and inflammation-induced manner. More recently, it has been found that PAP acts as an anti-inflammatory factor in vitro and in vivo. PAP expression can be induced by several pro- and anti-inflammatory cytokines and by itself through a JAK/STAT3-dependent pathway. PAP is able to activate the expression of the anti-inflammatory factor SOCS3 through the JAK/STAT3-dependent pathway. The JAK/STAT3/SOCS3 pathway seems to be a common point between PAP and several cytokines. Therefore, it is reasonable to propose that PAP is a new anti-inflammatory cytokine.
|
Authors | Daniel Closa, Yoshiharu Motoo, Juan L Iovanna |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 13
Issue 2
Pg. 170-4
(Jan 14 2007)
ISSN: 1007-9327 [Print] United States |
PMID | 17226896
(Publication Type: Editorial, Review)
|
Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- Cytokines
- Inflammation Mediators
- Lectins
- Lectins, C-Type
- Pancreatitis-Associated Proteins
- REG3A protein, human
- Reg3b protein, rat
- STAT3 Transcription Factor
|
Topics |
- Animals
- Antigens, Neoplasm
(chemistry, isolation & purification, metabolism)
- Biomarkers, Tumor
(chemistry, isolation & purification, metabolism)
- Cytokines
(chemistry, isolation & purification, metabolism)
- Inflammation Mediators
(chemistry, isolation & purification, metabolism)
- Lectins
(chemistry)
- Lectins, C-Type
(chemistry, isolation & purification, metabolism)
- Pancreatitis
(genetics, metabolism)
- Pancreatitis-Associated Proteins
- Rats
- STAT3 Transcription Factor
(metabolism)
|