Improved treatment of disseminated B16f10 melanoma in mice with anticancer drugs in combination with L-histidinol.

Abstract

An artificial hematogenous-metastasis model, in which B16f10 melanoma cells injected into the tail veins of C57/BL mice arrest in the lungs and proliferate as discrete pulmonary foci, was employed to examine effects of L-histidinol on the capacity of a number of conventional antineoplastic agents to manage disseminated disease. Treatment responses were evaluated by determining both the number of lung foci and/or by evaluating animal survival. L-Histidinol, on its own, was found to have a significant and dose-dependent capacity to reduce the number of lung foci and to extend survival of animals bearing disseminated B16f10 melanoma. L-Histidinol enhanced the ability of bis-chloroethylnitrosourea, 5-fluorouracil, and 1-beta-D-arabinofuranosulcytosine to reduce the number of lung foci. The latter combinations also gave marked improvements in survival, whether administered 1 or 7 days after the intravenous injection of tumor cells.

• Authors: R C Warrington, W D Fang
• Journal: Anticancer research (Anticancer Res) 1991 Sep-Oct Vol. 11 Issue 5 Pg. 1869-74 ISSN: 0250-7005 [Print] Greece
• PMID: 1722659 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytarabine
• Bleomycin
• Histidine
• Histidinol
• Doxorubicin
• Cisplatin
• Fluorouracil
• Carmustine
• Methotrexate

Topics

• Animals
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Carmustine (administration & dosage)
• Cisplatin (administration & dosage)
• Cytarabine (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Interactions
• Drug Screening Assays, Antitumor
• Female
• Fluorouracil (administration & dosage)
• Histidine (pharmacology)
• Histidinol (administration & dosage, antagonists & inhibitors)
• Lung Neoplasms (drug therapy, mortality, secondary)
• Melanoma, Experimental (drug therapy, mortality, secondary)
• Methotrexate (administration & dosage)
• Mice
• Mice, Inbred C57BL