On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: functionalization, conjugation and drug release kinetics.

Abstract

Superparamagnetic nickel ferrite nanoparticles functionalized with polyvinyl alcohol, polyethylene oxide and polymethacrylic acid (PMAA) polymers and subsequently conjugated with doxorubicin anti-cancer drug are studied for their use as a magnetic carrier for drug delivery. Fourier transform infrared spectroscopy enabled examination of the ability of the nanoparticles to be functionalized with polymers and conjugated with doxorubicin drug. The functionalized polymer-coated nanocrystalline nickel ferrites retain the magnetic characteristics of non-functionalized nanocrystalline nickel ferrites (superparamagnetism, absence of hysteresis, remanence and coercivity at room temperature), encouraging their application as a magnetic carrier for drug delivery. The PMAA-coated nanoferrites are demonstrated as being a potentially superior magnetically targeted drug carrier based on FTIR results and drug release kinetics in the absence and presence of an external magnetic field.

• Authors: S Rana, A Gallo, R S Srivastava, R D K Misra
• Journal: Acta biomaterialia (Acta Biomater) Vol. 3 Issue 2 Pg. 233-42 (Mar 2007) ISSN: 1742-7061 [Print] England
• PMID: 17224313 (Publication Type: Journal Article)

Chemical References

• Ferric Compounds
• Polymethacrylic Acids
• ferrite
• polymethacrylic acid
• Polyethylene Glycols
• Nickel
• Polyvinyl Alcohol

Topics

• Drug Delivery Systems
• Ferric Compounds (chemistry)
• Hydrogen-Ion Concentration
• Kinetics
• Magnetics
• Materials Testing
• Models, Chemical
• Nanoparticles (chemistry)
• Nickel (chemistry)
• Polyethylene Glycols (chemistry)
• Polymethacrylic Acids (chemistry)
• Polyvinyl Alcohol (chemistry)
• Spectroscopy, Fourier Transform Infrared
• Temperature