Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: CONCLUSIONS:
Selenomethionine modulates transcript levels of genes involved in a number of biological processes, including cell cycle/apoptosis androgen signaling, signal transduction and transcriptional regulation. Although the pathways affected paralleled in many ways those that are modulated by methylselenic acid, distinct differences in transcript patterns and effects on cell cycle regulation suggest that different selenium compounds could exert unique effects in prostate cells.
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Authors | Hongjuan Zhao, James D Brooks |
Journal | The Journal of urology
(J Urol)
Vol. 177
Issue 2
Pg. 743-50
(Feb 2007)
ISSN: 0022-5347 [Print] United States |
PMID | 17222674
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Organoselenium Compounds
- Selenomethionine
- methylselenic acid
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Topics |
- Humans
- Male
- Organoselenium Compounds
(pharmacology)
- Prostatic Neoplasms
(genetics, pathology)
- Selenomethionine
(pharmacology)
- Transcription, Genetic
(drug effects)
- Tumor Cells, Cultured
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