Pulmonary blastoma with germ cell (yolk sac) differentiation: report of two cases.

Abstract

Pulmonary blastoma is a rare lung neoplasm of disputed histogenesis and variable biologic behavior. Typical cases contain both epithelial and mesenchymal tissues, and a variety of patterns of differentiation have been described. While expression of oncofetal antigens in these tumors has been noted rarely, a coexisting component of germ cell tumor has not been reported previously. We describe the clinical and pathologic features of two cases of pulmonary blastoma having alpha-fetoprotein production and histologic areas of yolk sac tumor. We also report the finding of immunohistochemical staining of fetal lung tissue for alpha-fetoprotein.

• Authors: R J Siegel, C Bueso-Ramos, C Cohen, M Koss
• Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (Mod Pathol) Vol. 4 Issue 5 Pg. 566-70 (Sep 1991) ISSN: 0893-3952 [Print] United States
• PMID: 1722041 (Publication Type: Case Reports, Journal Article)

Chemical References

• alpha-Fetoproteins

Topics

• Adult
• Cell Transformation, Neoplastic (pathology)
• Female
• Humans
• Immunohistochemistry
• Lung (chemistry, embryology, pathology)
• Lung Neoplasms (chemistry, pathology)
• Mesonephroma (chemistry, pathology)
• Teratoma (chemistry, pathology)
• alpha-Fetoproteins (analysis)