| Abstract | Pulmonary blastoma is a rare lung neoplasm of disputed histogenesis and variable biologic behavior. Typical cases contain both epithelial and mesenchymal tissues, and a variety of patterns of differentiation have been described. While expression of oncofetal antigens in these tumors has been noted rarely, a coexisting component of germ cell tumor has not been reported previously. We describe the clinical and pathologic features of two cases of pulmonary blastoma having alpha-fetoprotein production and histologic areas of yolk sac tumor. We also report the finding of immunohistochemical staining of fetal lung tissue for alpha-fetoprotein. |
| Authors | R J Siegel, C Bueso-Ramos, C Cohen, M Koss
(Affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.)
|
| Journal | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
(Mod Pathol)
Vol. 4
Issue 5
Pg. 566-70
(Sep 1991)
ISSN: 0893-3952 UNITED STATES |
| PMID | 1722041
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
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| Topics |
- Adult
- Cell Transformation, Neoplastic
(pathology)
- Female
- Humans
- Immunohistochemistry
- Lung
(chemistry, embryology, pathology)
- Lung Neoplasms
(chemistry, pathology)
- Mesonephroma
(chemistry, pathology)
- Teratoma
(chemistry, pathology)
- alpha-Fetoproteins
(analysis)
|
