| Abstract | INTRODUCTION: Canavan disease is a megalencephalic leukodystrophy due to deficiency of the enzyme aspartoacylase. Proton MR spectroscopy finding of elevated N-acetyl-L: -aspartate is considered diagnostic of Canavan disease. CASE REPORT: We report a case of Canavan disease, which showed restricted diffusion in diffusion-weighted imaging and discuss the cause of it. |
| Authors | S G Srikanth, H S Chandrashekar, K Nagarajan, P N Jayakumar
(Affiliation: Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India. sgsrikanth at yahoo.com)
|
| Journal | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
(Childs Nerv Syst)
Vol. 23
Issue 4
Pg. 465-8
(Apr 2007)
ISSN: 0256-7040 Germany |
| PMID | 17219235
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Aspartic Acid
- Amidohydrolases
- aspartoacylase
|
| Topics |
- Amidohydrolases
(metabolism)
- Aspartic Acid
(metabolism)
- Canavan Disease
(diagnosis, metabolism)
- Diffusion Magnetic Resonance Imaging
- Humans
- Infant
- Magnetic Resonance Spectroscopy
(methods)
- Male
|
