[Isovolemic hemodilution on non-arteritic anterior optic neuropathy. Initial results of a randomized study].
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| Abstract |
As there is no generally accepted treatment for non-inflammatory anterior ischemic optic neuropathy, we have started a randomized, controlled clinical trial on isovolemic hemodilution. In this study all patients received a basic treatment of 75 mg of acetylsalicyclic acid daily. Patients were then randomly assigned to either a group without additional therapy or a group with isovolemic hemodilution. Isovolemic hemodilution was carried out over 6 weeks by several blood-letting procedures and replacement of volume by infusion of hydroxyethyl starch solutions (PCV down to 35-32%). So far, 21 patients have fulfilled the inclusion criteria (symptoms less than or equal to 30 days, no medical contraindications, no giant-cell arteritis), and since they matched for age, duration of symptoms, cardiovascular risk factors, they could be observed for at least 3 months. Although only 1 of 10 control patients hat better visual acuity after 3 months; 6 out of 11 hemodiluted patients had better vision after treatment (p = 0.024). These results indicate that isovolemic hemodilution most likely has a beneficial effect on the visual prognosis of patients with anterior ischemic neuropathy.
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| Authors | L L Hansen, J Wiek, M Danisevskis, W Schrader |
| Journal | Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft (Fortschr Ophthalmol) Vol. 88 Issue 5 Pg. 487-9 ( 1991) ISSN: 0723-8045 [Print] Germany |
| Vernacular Title | Isovolämische Hämodilution bei nichtarteriitischer anteriorer Optikusneuropathie. Erste Ergebnisse einer randomisierten Studie. |
| PMID | 1721887 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial) |
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