[The beneficial effects of lipid-lowering therapy with xuezhikang on cardiac events and total mortality in coronary heart disease patients with or without hypertension: a random, double-blinded, placebo controlled clinical trial].

Abstract

OBJECTIVE:

To evaluate whether lipid-lowering therapy with Xuezhikang can reduce the risk of cardiac events and total mortality in coronary heart disease (CHD) patients with or without hypertension.

METHODS:

In this random, double-blinded, placebo controlled clinical trial, 2704 patients with hypertension and 2166 patients without hypertension were enrolled and capsule Xuezhikang 0.6 g Bid or placebo on the top of conventional therapy without other lipid-lowering drugs. The mean follow-up period was four years. The primary end-points were nonfatal myocardial infarction and total mortality.

RESULTS:

Compared to placebo group, the incidence of cardiac events was reduced by 44.0% (P<0.0001) and 47.4% (P<0.0001) respectively in CHD patients with or without hypertension, and the total mortality was lowered by 35.8% (P=0.0012) and 28.6% (P=0.0737) respectively in CHD patients with or without hypertension. There was no significant difference in side effects between study groups.

CONCLUSION:

Xuezhikang can reduce the cardiac events and mortality in CHD patients with or without hypertension.

• Authors: Bao-min DU, Zong-liang Lu, Zuo Chen, Yang-feng Wu
• Journal: Zhonghua xin xue guan bing za zhi (Zhonghua Xin Xue Guan Bing Za Zhi) Vol. 34 Issue 10 Pg. 890-4 (Oct 2006) ISSN: 0253-3758 [Print] China
• PMID: 17217713 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Hypolipidemic Agents
• Lipids
• xuezhikang

Topics

• Adolescent
• Adult
• Aged
• Coronary Disease (drug therapy, mortality)
• Double-Blind Method
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Hypertension (complications, drug therapy, mortality)
• Hypolipidemic Agents (therapeutic use)
• Lipids (blood)
• Middle Aged
• Phytotherapy
• Survival Rate