Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation.

Abstract

Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.

• Authors: Jeroen S Goede, Benjamin Misselwitz, Christian Taverna, Urs Schanz, Angela Dispenzieri, Yvonne Hummel, Ralph M Trüeb, Jörg Fehr
• Journal: Annals of hematology (Ann Hematol) Vol. 86 Issue 4 Pg. 303-6 (Apr 2007) ISSN: 1432-0584 [Electronic] Germany
• PMID: 17216474 (Publication Type: Case Reports, Letter)

Topics

• Adult
• Humans
• Male
• Necrobiotic Disorders (pathology, surgery)
• Skin Diseases (pathology, surgery)
• Stem Cell Transplantation (methods)
• Transplantation, Autologous
• Treatment Outcome