| Abstract | This study investigated an aggressive treatment program for stage 2 systolic hypertension (pretreatment systolic blood pressure [SBP] > or = 160 mm Hg) using the angiotensin receptor blocker olmesartan medoxomil (OM) and hydrochlorothiazide (HCTZ). In this open-label, 16-week trial, 170 subjects received OM 20 mg/d for 3 weeks. If seated SBP/diastolic BP remained > or = 120/80 mm Hg, subjects were advanced to successive 3-week courses of OM 40 mg/d, OM/HCTZ 40/12.5 mg/d, and OM/HCTZ 40/25 mg/d. OM 20 mg/d reduced mean SBP by 16.9 mm Hg (P<.001), and there were further dose-dependent decreases in mean SBP to a maximum of 34.5 mm Hg with OM/HCTZ 40/25 mg/d. At study end, 75.1% of subjects achieved SBP goal (<140 mm Hg) and 16.0% achieved SBP normalization (<120 mm Hg). Treatment was well tolerated at all doses. The addition of HCTZ did not change serum potassium levels but resulted in a dose-independent but not symptomatic increase in serum glucose and uric acid. The authors conclude that an OM-based regimen, with or without HCTZ in conventional doses, is effective in controlling and normalizing BP in stage 2 systolic hypertension. |
| Authors | Joseph L Izzo Jr, Joel M Neutel, Tonous Silfani, Robert Dubiel, Findlay Walker
(Affiliation: Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14215, USA. jizzo at ams.ecmc.edu)
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| Journal | Journal of clinical hypertension (Greenwich, Conn.)
(J Clin Hypertens (Greenwich))
Vol. 9
Issue 1
Pg. 36-44
(Jan 2007)
ISSN: 1524-6175 United States |
| PMID | 17215657
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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| Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Diuretics
- Imidazoles
- Tetrazoles
- olmesartan
- Hydrochlorothiazide
|
| Topics |
- Aged
- Angiotensin II Type 1 Receptor Blockers
(therapeutic use)
- Blood Pressure
(drug effects)
- Diuretics
(therapeutic use)
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Humans
- Hydrochlorothiazide
(therapeutic use)
- Hypertension
(drug therapy, physiopathology)
- Imidazoles
(therapeutic use)
- Male
- Middle Aged
- Prospective Studies
- Single-Blind Method
- Tetrazoles
(therapeutic use)
- Treatment Outcome
|
