| Abstract | OBJECTIVE: The objective of this study is to evaluate the inflammatory response caused by endovascular stents in the treatment of aortic aneurysms. METHODS: Twenty-five patients underwent endovascular stent treatment from March through December 2005. The evolution of mediators (sedimentation velocity, C reactive protein, interleukin-6, interleukin-8, tumor necrosis factor-alpha, intercellular adhesion molecule-1, l-selectin), inflammatory cells (leukocytes, lymphocytes, platelets), serum creatinine and body temperature within preoperative period and in the following postoperative periods--1, 6, 24 and 48 h, 7 days, 1-3 months, was analyzed. In order to achieve statistic significance, Friedman test and Wilcoxon test were used, with index of significance of 5% (p<0.05). RESULTS: Peak values of sedimentation velocity, C reactive protein and interleukin-6 were observed at 7 days (p<0.0001), 48 h (p<0.0001) and 24h (p<0.0001), respectively. Tumor necrosis factor-alpha and interleukin-8 did not show statistically significant variability during the entire follow-up. In terms of intercellular adhesion molecule-1 and l-selectin, their expressive values were found in late phase of follow-up, although without statistical significance. Elevation of leukocytes count occurred in premature phase of follow-up (p<0.0001), while lymphocyte and platelet count occurred in a late phase of follow-up (p<0.0001). Serum levels of creatinine did not show significant variability during follow-up. The period between 24 and 48 h corresponded to major frequency for fever (p<0.0001). CONCLUSION: Individual mediators analysis and inflammatory cells demonstrated variability of their values during postoperative follow-up. This could help in the analysis of the inflammatory response evolution caused by endovascular stent treatment for aortic aneurysms in premature and late phases after implantation of the vascular prosthesis. |
| Authors | Edmo Atique Gabriel, Rafael Fagionato Locali, Carla Cristina Romano, Alberto José da Silva Duarte, José Honório Palma, Enio Buffolo
(Affiliation: Federal University of Sao Paulo-Paulista School of Medicine, Division of Cardiovascular Surgery, Heart Hospital of Sao Paulo (HCOR), Tropical Illnesses Institute of University of Sao Paulo, Brazil. edag at uol.com.br)
|
| Journal | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
(Eur J Cardiothorac Surg)
Vol. 31
Issue 3
Pg. 406-12
(Mar 2007)
ISSN: 1010-7940 Germany |
| PMID | 17215133
(Publication Type: Journal Article)
|
| Chemical References |
- Inflammation Mediators
- Interleukin-6
- Interleukin-8
- Tumor Necrosis Factor-alpha
- Intercellular Adhesion Molecule-1
- L-Selectin
|
| Topics |
- Adult
- Aged
- Aged, 80 and over
- Aortic Aneurysm
(surgery)
- Aortic Aneurysm, Abdominal
(surgery)
- Aortic Aneurysm, Thoracic
(surgery)
- Blood Vessel Prosthesis Implantation
(adverse effects)
- Female
- Follow-Up Studies
- Humans
- Inflammation
(etiology)
- Inflammation Mediators
(blood)
- Intercellular Adhesion Molecule-1
(blood)
- Interleukin-6
(blood)
- Interleukin-8
(blood)
- L-Selectin
(blood)
- Male
- Middle Aged
- Stents
(adverse effects)
- Tumor Necrosis Factor-alpha
(blood)
|
