Role of MAPKs in angiotensin II-induced steroidogenesis in rat glomerulosa cells.

Abstract

Angiotensin II is one of the most important stimuli of rat adrenal glomerulosa cells, stimulating both steroid secretion and growth. In a previous report, we had shown that Ang II promotes cellular hypertrophy, but not proliferation, in rat adrenal glomerulosa cells maintained in primary culture for 3 days. The inhibition of proliferation and stimulation of hypertrophy induced by Ang II involves both p42/p44(mapk) and p38 MAPK activation. The increase in cell protein content induced by Ang II entails formation of a cortical actin ring and Rac-dependent activation of p42/p44(mapk) and p38 MAPK. The present study summarizes these results and provides evidences that Ang II-induced activation of p42/p44(mapk) and p38 MAPK are implicated in aldosterone secretion by enhancing expression of specific steroidogenic proteins such as StAR and 3beta-HSD.

• Authors: Mélissa Otis, Nicole Gallo-Payet
• Journal: Molecular and cellular endocrinology (Mol Cell Endocrinol) Vol. 265-266 Pg. 126-30 (Feb 2007) ISSN: 0303-7207 [Print] Ireland
• PMID: 17215073 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Steroids
• Angiotensin II
• Aldosterone
• Mitogen-Activated Protein Kinase 1
• Mitogen-Activated Protein Kinase 3
• Mitogen-Activated Protein Kinases
• p38 Mitogen-Activated Protein Kinases
• rho GTP-Binding Proteins

Topics

• Aldosterone (metabolism)
• Angiotensin II (metabolism)
• Animals
• Cell Proliferation
• Mitogen-Activated Protein Kinase 1 (metabolism)
• Mitogen-Activated Protein Kinase 3 (metabolism)
• Mitogen-Activated Protein Kinases (metabolism)
• Rats
• Steroids (biosynthesis)
• Zona Glomerulosa (cytology, metabolism)
• p38 Mitogen-Activated Protein Kinases (metabolism)
• rho GTP-Binding Proteins (metabolism)