| Abstract | Methotrexate has been used as an important alternative therapy in the treatment of various rheumatic diseases. Life threatening marrow suppression in end-stage renal disease patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis has been reported. A 33-year-old woman with systemic lupus erythematosus undergoing chronic peritoneal dialysis developed severe mucositis and pancytopenia after low-dose methotrexate treatment for arthritis. The leukocyte count recovered after methotrexate was withdrawn but a leukemoid blood picture developed during her recovery. No evidence of leukemia was found on bone marrow biopsy. The leukocyte count gradually returned to normal with conservative therapy. |
| Authors | Chiao-Ying Sun, Hou-Chang Lin, Yung-Chih Chen, Chi-Ren Tsai, Mai-Szu Wu
(Affiliation: Division of Nephrology, Chang Gung Memorial Hospital. 222, Maijin Rd., Anle Chiu, Keelung, Taiwan 204, ROC.)
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| Journal | Chang Gung medical journal
(Chang Gung Med J)
2006 Sep-Oct
Vol. 29
Issue 5
Pg. 513-7 China (Republic : 1949- ) |
| PMID | 17214397
(Publication Type: Case Reports, Journal Article)
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| Chemical References |
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| Topics |
- Adult
- Female
- Humans
- Leukemoid Reaction
(chemically induced)
- Lupus Erythematosus, Systemic
(therapy)
- Methotrexate
(adverse effects)
- Pancytopenia
(chemically induced)
- Peritoneal Dialysis, Continuous Ambulatory
|
