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Thymidine kinase 1 in serum predicts increased risk of distant or loco-regional recurrence following surgery in patients with early breast cancer.

AbstractBACKGROUND:
The prognostic value of the concentration of serum thymidine kinase 1 (S-TK1) with regard to recurrence in low risk breast cancer patients, 3 months after surgery was evaluated.
PATIENTS AND METHODS:
The concentration of S-TK1 in serum was determined in 120 breast cancer patients at the time of surgery and in 67 patients 3 months after surgery, by anti-TK1 chicken IgY antibody, using a dot-blot immuno-assay. The S-TK1 concentration was compared with the serological activity of thymidine kinase (STK) and of carbohydrate antigen (CA 15-3).
RESULTS:
A statistically significant trend (unadjusted) was found for recurrence (distant or loco-regional) in patients with a higher S-TK1 concentration, as compared with patients with a lower S-TK1 concentration. A multivariate analysis gave the same results. The hazard rate ratio for developing distant and/or loco-regional recurrence in patients with a higher S-TK1 concentration was about six to seven times higher than in patients with a lower S-TK1 concentration.
CONCLUSION:
Our results indicate that the S-TK1 concentration is higher in patients developing distant and/or loco-regional recurrence 3 months post-surgery.
AuthorsQimin He, Tommy Fornander, Hemming Johansson, Ulla Johansson, Guo Zhu Hu, Lars-Erik Rutqvist, Sven Skog
JournalAnticancer research (Anticancer Res) 2006 Nov-Dec Vol. 26 Issue 6C Pg. 4753-9 ISSN: 0250-7005 [Print] Greece
PMID17214336 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Hormonal
  • Biomarkers, Tumor
  • Tamoxifen
  • Goserelin
  • Thymidine Kinase
  • thymidine kinase 1
Topics
  • Adult
  • Antineoplastic Agents, Hormonal (administration & dosage, therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Biomarkers, Tumor (blood)
  • Breast Neoplasms (drug therapy, enzymology, pathology, surgery)
  • Female
  • Goserelin (administration & dosage, therapeutic use)
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local (enzymology, pathology)
  • Predictive Value of Tests
  • Risk Factors
  • Tamoxifen (administration & dosage, therapeutic use)
  • Thymidine Kinase (blood)

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