Abstract | BACKGROUND: The prognostic value of the concentration of serum thymidine kinase 1 (S-TK1) with regard to recurrence in low risk breast cancer patients, 3 months after surgery was evaluated. PATIENTS AND METHODS: The concentration of S-TK1 in serum was determined in 120 breast cancer patients at the time of surgery and in 67 patients 3 months after surgery, by anti-TK1 chicken IgY antibody, using a dot-blot immuno-assay. The S-TK1 concentration was compared with the serological activity of thymidine kinase (STK) and of carbohydrate antigen (CA 15-3). RESULTS: A statistically significant trend (unadjusted) was found for recurrence (distant or loco-regional) in patients with a higher S-TK1 concentration, as compared with patients with a lower S-TK1 concentration. A multivariate analysis gave the same results. The hazard rate ratio for developing distant and/or loco-regional recurrence in patients with a higher S-TK1 concentration was about six to seven times higher than in patients with a lower S-TK1 concentration. CONCLUSION: Our results indicate that the S-TK1 concentration is higher in patients developing distant and/or loco-regional recurrence 3 months post-surgery.
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Authors | Qimin He, Tommy Fornander, Hemming Johansson, Ulla Johansson, Guo Zhu Hu, Lars-Erik Rutqvist, Sven Skog |
Journal | Anticancer research
(Anticancer Res)
2006 Nov-Dec
Vol. 26
Issue 6C
Pg. 4753-9
ISSN: 0250-7005 [Print] Greece |
PMID | 17214336
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Hormonal
- Biomarkers, Tumor
- Tamoxifen
- Goserelin
- Thymidine Kinase
- thymidine kinase 1
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Topics |
- Adult
- Antineoplastic Agents, Hormonal
(administration & dosage, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Biomarkers, Tumor
(blood)
- Breast Neoplasms
(drug therapy, enzymology, pathology, surgery)
- Female
- Goserelin
(administration & dosage, therapeutic use)
- Humans
- Middle Aged
- Neoplasm Recurrence, Local
(enzymology, pathology)
- Predictive Value of Tests
- Risk Factors
- Tamoxifen
(administration & dosage, therapeutic use)
- Thymidine Kinase
(blood)
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