| Abstract | OBJECTIVES: To compare the response to treatment with tumour necrosis factor (TNF) inhibitors and methotrexate (MTX) monotherapy in patients with psoriatic arthritis (PsA) within a real-life clinical setting. METHODS: We analysed data from an ongoing longitudinal, observational multicentre study in Norway. Our data comprised 526 cases of patients with PsA who received either anti-TNF treatment (n = 146) or MTX monotherapy (n = 380) and were followed for at least 6 months with measures of disease activity, health status and utility scores. A propensity score was computed to adjust for channelling bias. The changes in measures of disease activity and health-related quality of life from baseline to 3- and 6-month follow-up were compared between the groups with adjustments for the baseline value of the dependent variable and the propensity score (analyses of covariance (ANCOVA)). RESULTS: The groups were significantly different at baseline with respect to demographic and disease activity measures. The variables included in the propensity score were age, sex, number of previous disease modifying anti-rheumatic drugs (DMARDs), presence of erosive disease, treatment centre and investigator's global assessment. The adjusted changes at 6 months were significantly larger in the anti-TNF group for ESR, DAS-28, M-HAQ, patient's assessments of pain, fatigue and global disease activity on a visual analogue scale (VAS) and 4 out of 8 SF-36 dimensions. CONCLUSIONS: Clinical improvement was superior with TNF inhibitors compared to MTX monotherapy in patients with PsA, when assessed in this setting of daily clinical practice. |
| Authors | M S Heiberg, C Kaufmann, E Rødevand, K Mikkelsen, W Koldingsnes, P Mowinckel, T K Kvien
(Affiliation: Dept. of Rheumatology, Diakonhjemmet Hospital, Box 23 Vinderen, 0319 Oslo, Norway. marte.schrumpf at diakonsyk.no)
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| Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 66
Issue 8
Pg. 1038-42
(Aug 2007)
ISSN: 0003-4967 England |
| PMID | 17213251
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antibodies, Monoclonal
- Antirheumatic Agents
- Immunoglobulin G
- Immunosuppressive Agents
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha
- adalimumab
- infliximab
- TNFR-Fc fusion protein
- Methotrexate
|
| Topics |
- Adult
- Aged
- Antibodies, Monoclonal
(therapeutic use)
- Antirheumatic Agents
(therapeutic use)
- Arthritis, Psoriatic
(drug therapy, pathology)
- Chi-Square Distribution
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Humans
- Immunoglobulin G
(therapeutic use)
- Immunosuppressive Agents
(therapeutic use)
- Joints
(pathology)
- Logistic Models
- Male
- Methotrexate
(therapeutic use)
- Middle Aged
- Norway
- Pain
- Receptors, Tumor Necrosis Factor
(therapeutic use)
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
|
