Recurrent unbalanced whole-arm t(1;10)(q10;p10) in myelodysplastic syndrome: a case report and literature review.

Abstract

We report a patient with myelodysplastic syndrome (refractory anemia) showing the karyotype 46,XY,+1,der(1;10)(q10;p10), resulting in trisomy 1q and monosomy 10q abnormality. This finding suggests that either trisomy of 1q or centromeric connection between chromosomes 1 and 10, rather than the absence of 10q, might be essential toward neoplastic transformation.

• Authors: Omar Ferkad Faraj Odish, Akihiko Gotoh, Yi-Chang Liu, Nohoko Shoji, Yukihiko Kimura, Atsushi Kodama, Kazuma Ohyashiki
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 172 Issue 2 Pg. 165-7 (Jan 15 2007) ISSN: 0165-4608 [Print] United States
• PMID: 17213027 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Allelic Imbalance
• Chromosomes, Human, Pair 1 (genetics)
• Chromosomes, Human, Pair 10 (genetics)
• Humans
• Male
• Middle Aged
• Myelodysplastic Syndromes (genetics)
• Neoplasm Recurrence, Local (genetics)
• Translocation, Genetic