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Topiramate in frontal lobe epilepsy.

AbstractBACKGROUND: Frontal lobe epilepsy (FLE) is a type of epilepsy that is difficult to treat and there are few studies about the use of topiramate (TPM). AIM OF THE STUDY: To evaluate the efficacy and tolerability of TPM monotherapy in FLE. METHODS: The study group consisted of 55 (33 male; 22 female) patients. TPM was administered as a first drug (n = 16) or converted after previous treatment (n = 39). All patients were followed every 3 months for at least 1 year. The patients were subdivided into two groups: 'newly diagnosed' patients and 'difficult-to-treat' patients. RESULTS: Overall, all patients completed the 1-year study. At the end of follow-up, 10 patients showed disappearance of seizures and 33 patients showed improvement in seizure frequency. In particular, among the newly diagnosed patients 6/16 patients showed complete cessation of seizures and 5/16 patients showed very good response; in the other group, 4/39 patients showed complete cessation and 4/39 patients showed a very good response. No patients of both groups had worsening of seizures. No treatment-limiting adverse events associated with TPM were reported. CONCLUSIONS: TPM is effective in newly diagnosed patients with FLE; TPM can be considered for the treatment of FLE.
AuthorsA Verrotti, V Sofia, E Franzoni, G Coppola, R Manco, G L Ciambra, S Savasta, F Chiarelli, P Iannetti (Affiliation: Department of Pediatrics, University of Chieti, Chieti, Italy. averrott at unich.it)
JournalActa neurologica Scandinavica (Acta Neurol Scand) Vol. 115 Issue 2 Pg. 132-5 (Feb 2007) ISSN: 0001-6314 Denmark
PMID17212619 (Publication Type: Journal Article, Multicenter Study)
Chemical References
  • Anticonvulsants
  • Fructose
  • topiramate
Topics
  • Adolescent
  • Adult
  • Anticonvulsants (adverse effects, therapeutic use)
  • Child
  • Child, Preschool
  • Epilepsy, Frontal Lobe (drug therapy)
  • Female
  • Follow-Up Studies
  • Fructose (adverse effects, analogs & derivatives, therapeutic use)
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Patient Compliance
  • Retrospective Studies
  • Treatment Outcome