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Enantioselective intramolecular aldol addition/dehydration reaction of a macrocyclic diketone: synthesis of the musk odorants (R)-muscone and (R,Z)-5-muscenone.

AuthorsOliver Knopff, Jérôme Kuhne, Charles Fehr (Affiliation: Firmenich SA, Corporate R&D Division, B.P. 239, 1211, Genève 8, Switzerland. oliver.knopff at firmenich.com)
JournalAngewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 46 Issue 8 Pg. 1307-10 ( 2007) ISSN: 1433-7851 Germany
PMID17211908 (Publication Type: Journal Article)
Chemical References
  • (R,Z)-5-muscenone
  • Aldehydes
  • Cycloparaffins
  • Ketones
  • Macrocyclic Compounds
  • 3-hydroxybutanal
  • muscone
  • Water
Topics
  • Aldehydes (chemistry)
  • Cycloparaffins (chemical synthesis, chemistry)
  • Ketones (chemical synthesis, chemistry)
  • Kinetics
  • Macrocyclic Compounds (chemical synthesis, chemistry)
  • Models, Molecular
  • Molecular Structure
  • Stereoisomerism
  • Water (chemistry)