Hb Indianapolis [beta112 (G14) Cys-->Arg] as the probable cause of moderate hemolytic anemia and renal damage in a Brazilian patient.

Abstract

Hemoglobin (Hb) Indianapolis [beta112 (G14) Cys-->Arg] is a rare and slightly unstable beta-globin variant. All carriers described to date were clinically normal with only mild reticulocytosis. We report here a case of a Brazilian patient in whom hemolytic anemia and acute renal failure were probably caused by the presence of this variant.

• Authors: A Fattori, E M Kimura, D M Albuquerque, D M Oliveira, F F Costa, M F Sonati
• Journal: American journal of hematology (Am J Hematol) Vol. 82 Issue 7 Pg. 672-5 (Jul 2007) ISSN: 0361-8609 [Print] United States
• PMID: 17211844 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hemoglobins, Abnormal
• hemoglobin Indianapolis
• Arginine
• Cysteine

Topics

• Adult
• Anemia, Hemolytic (genetics, metabolism, pathology)
• Arginine (genetics, metabolism)
• Base Sequence
• Brazil
• Child
• Child, Preschool
• Cysteine (genetics, metabolism)
• Female
• Hemoglobins, Abnormal (genetics, metabolism)
• Humans
• Kidney (metabolism, pathology)
• Male
• Molecular Sequence Data