A case-control study on the association of human leukocyte antigen-A*9 and -B*15 alleles with generalized aggressive periodontitis in an Indian population.

Abstract

BACKGROUND:

The genes encoding the human leukocyte antigens (HLAs; major histocompatibility complex [MHC]) have been considered candidate markers for periodontitis because they are involved in regulating immune responses. Several studies have examined this association, and despite the inconclusive results, the antigens HLA-A9 and HLA-B15 have been found to be consistently associated with the destructive forms of periodontitis in many populations. Ethnic factors are considered to be a major variable for evaluating the predisposition to the disease. The purpose of the present study was to: 1) assess the association of HLA-A*9 and HLA-B*15 with generalized aggressive periodontitis (GAgP) and 2) evaluate the role of these genetic risk factors in influencing the severity of GAgP in a South Indian population.

METHODS:

Forty GAgP patients (cases) and 80 periodontally and systemically healthy subjects (controls) participated in this study. HLA-A*9 and HLA-B*15 typing was carried out using the polymerase chain reaction with sequence specific primers (PCR-SSP)-based molecular method.

RESULTS:

HLA-B*15 was a significant risk factor for GAgP and was positively correlated with the disease severity, whereas HLA-A*9 had no association with the disease. The haplotype of HLA-A*9:B*15 did not impart any additional risk for GAgP compared to that imparted by HLA-B*15 alone.

CONCLUSIONS:

To our knowledge, this is the first report on HLA-B*15 association with GAgP in an Indian population. The finding of HLA-B*15 as a risk factor may have potential use in the future management of GAgP. The precise disease-causing mechanism of this HLA disease association and whether this association is "causal" or "casual" need to be evaluated further.

• Authors: T Roshna, Rasmi Thomas, K Nandakumar, Moinak Banerjee
• Journal: Journal of periodontology (J Periodontol) Vol. 77 Issue 12 Pg. 1954-63 (Dec 2006) ISSN: 0022-3492 [Print] United States
• PMID: 17209778 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-A Antigens
• HLA-A9 antigen
• HLA-B Antigens
• HLA-B15 Antigen

Topics

• Adult
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• HLA-A Antigens (genetics)
• HLA-B Antigens (genetics)
• HLA-B15 Antigen
• Humans
• India (epidemiology)
• Male
• Oral Hygiene Index
• Periodontal Attachment Loss (etiology)
• Periodontitis (complications, ethnology, genetics, immunology)
• Polymorphism, Genetic
• Reference Values
• Severity of Illness Index
• Sex Factors
• White People