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Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility.

Abstract
A murine monoclonal antibody (M31-15) was identified using the penetration-inhibiting assay of a human lung adenocarcinoma cell line (MAC10) and remarkably inhibited the phagokinetic tract motility of various cancer cell lines. The antigen, motility-related protein (MRP-1), recognized by M31-15, was 25- and 28-kD proteins, and M31-15 was used to isolate a cDNA clone from a human breast carcinoma cDNA library. Sequence analysis revealed that MRP-1 had strong similarity with a B cell surface antigen (CD37), a melanoma-associated antigen (ME491), the target of an antiproliferative antibody (TAPA-1), a human tumor-associated antigen (CO-029), and the Sm23 antigen of the trematode parasite Schistosoma mansoni.
AuthorsM Miyake, M Koyama, M Seno, S Ikeyama
JournalThe Journal of experimental medicine (J Exp Med) Vol. 174 Issue 6 Pg. 1347-54 (Dec 01 1991) ISSN: 0022-1007 [Print] United States
PMID1720807 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Surface
  • CD9 protein, human
  • Cd9 protein, mouse
  • Epitopes
  • Membrane Glycoproteins
  • Proteins
  • Tetraspanin 29
  • DNA
Topics
  • Adenocarcinoma (immunology)
  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal (immunology)
  • Antigens, CD
  • Antigens, Surface (analysis, genetics, immunology)
  • Base Sequence
  • Cell Movement
  • DNA (isolation & purification)
  • Epitopes (analysis)
  • Humans
  • Immunohistochemistry
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Proteins (analysis)
  • Tetraspanin 29
  • Tumor Cells, Cultured

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