Trial participation and vaccine desirability for Vi polysaccharide typhoid fever vaccine in Hue City, Viet Nam.

Abstract

OBJECTIVES:

To identify demand for Vi typhoid fever vaccine for school-age children; obstacles and enabling factors for vaccine delivery; and socio-behavioural factors associated with trial participation and possible predictors of future vaccine acceptance, in Hue City, Viet Nam.

METHODS:

Pre- and post-trial surveys of randomly selected households with children aged 6-17 years. Simple multinomial logistic analyses for ratios of relative risks (RRR) and significance on trial participation by demographics and variables related to typhoid fever, vaccination, and pre-trial experiences with information and consents. Multiple logistic regressions to assess differences in participation based on child's characteristics.

RESULTS:

As many as 62.6% of households let all school age children participate, 10.2% let some participate, and 26.8% let none of their children participate in the trial. Factors associated with all children participating included past use of healthcare facilities (RRR, 0.45; 95% CI, 0.24-0.83), knowledge of vaccines (RRR, 0.17; 95% CI, 0.03-0.86), and perceived causes of typhoid fever (RRR, 0.90; 95% CI, 0.81-0.99). Factors associated with some children participating included utilization of healthcare facilities (RRR, 0.08; 95% CI, 0.01-0.66) and perceived severity of typhoid fever (RRR, 0.64; 95% CI 0.46-0.88). Participation was associated with satisfaction regarding pre-vaccination information and consent procedures. Children and adolescents were active decision-makers. Only 14 of 461 (2.2%) respondents would not use the Vi vaccine in the future for their child(ren).

CONCLUSIONS:

Inter-related factors contribute to participation in a clinical vaccine trial, which may differ from desire to participate in a public health campaign. Educational campaigns need to be targeted to children and adolescents, and consideration for assent procedures for minors. Obtaining informed consent may affect trial participation within a social and political system unaccustomed to these procedures.

• Authors: Linda M Kaljee, Van Pham, Nguyen Dinh Son, Nguyen Thai Hoa, Vu Dinh Thiem, Do Gia Canh, Le Thi Kim Thoa, Mohammad Ali, Rion Leon Ochiai, M Carolina Danovaro-Holliday, Camilo J Acosta, Bonita Stanton, John Clemens
• Journal: Tropical medicine & international health : TM & IH (Trop Med Int Health) Vol. 12 Issue 1 Pg. 25-36 (Jan 2007) ISSN: 1360-2276 [Print] England
• PMID: 17207145 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Polysaccharides, Bacterial
• Typhoid-Paratyphoid Vaccines
• Vi polysaccharide vaccine, typhoid

Topics

• Adolescent
• Adult
• Child
• Culture
• Family Characteristics
• Female
• Health Care Surveys (methods)
• Health Knowledge, Attitudes, Practice
• Humans
• Informed Consent (psychology)
• Male
• Middle Aged
• Parents
• Patient Acceptance of Health Care (psychology)
• Patient Education as Topic (standards)
• Patient Participation (psychology)
• Patient Satisfaction
• Polysaccharides, Bacterial (therapeutic use)
• Regression Analysis
• Severity of Illness Index
• Typhoid Fever (epidemiology, prevention & control, psychology)
• Typhoid-Paratyphoid Vaccines (therapeutic use)
• Vietnam (epidemiology)