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Serum progastrin-releasing peptide levels followed by whole-body positron emission tomography detects early recurrence of small-cell lung cancer.

Abstract
A 65-year-old male smoker with severe COPD was diagnosed with limited-stage small-cell lung cancer. After receiving cisplatin/irinotecan, serum progastrin-releasing peptide (ProGRP) levels decreased to within the reference values and the lesions were markedly reduced in size. A whole-body 18F-fluorodeoxyglucose PET (FDG-PET) scan confirmed complete remission. During follow up, serum ProGRP levels increased, and a whole-body FDG-PET scan detected recurrence at the hilar lymph node that had been negative on CT. Complete remission was again achieved with second-line chemotherapy (cisplatin/etoposide) and local irradiation to the hilar lymph node. Monitoring serum ProGRP levels, followed by whole-body FDG-PET when indicated, may improve the clinical management of patients with small-cell lung cancer after initial complete remission.
AuthorsHiroyuki Yamaguchi, Hiroshi Soda, Takeshi Kitazaki, Hirofumi Nakano, Satoru Fujino, Yoichi Nakamura, Shigeru Kohno
JournalRespirology (Carlton, Vic.) (Respirology) Vol. 12 Issue 1 Pg. 137-9 (Jan 2007) ISSN: 1323-7799 [Print] Australia
PMID17207039 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Peptide Fragments
  • Peptides
  • Recombinant Proteins
  • pro-gastrin-releasing peptide (31-98)
Topics
  • Aged
  • Biomarkers, Tumor (blood)
  • Carcinoma, Small Cell (blood, diagnostic imaging, pathology)
  • Disease Progression
  • Fatal Outcome
  • Humans
  • Lung Neoplasms (blood, diagnostic imaging, pathology)
  • Male
  • Neoplasm Recurrence, Local (blood, diagnostic imaging, pathology)
  • Peptide Fragments (blood)
  • Peptides (blood)
  • Positron-Emission Tomography (methods)
  • Recombinant Proteins (blood)

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