Abstract | BACKGROUND AND PURPOSE: Although the continuous perfusion of antispasmodic drugs has been the traditional mainstay in the treatment of renal colic, the results more often than not are unsatisfactory. Our hypothesis was that a continuous intravenous (IV) drip of tramadol would be an effective and safe alternative. PATIENTS AND METHODS: In this prospective study, 300 patients with renal colic were randomized into four treatment groups, single blind for the patients. At the start, all received an anti-inflammatory drug intramuscularly and an antiemetic and antispasmodic IV. Group A was given the classical IV antispasmodic perfusion combined with a sham drip. Group B received the classical antispasmodic perfusion in combination with a tramadol drip. Group C had a sham perfusion and drip. Group D received a sham perfusion and tramadol drip. There was no significant difference in the degree of pain between the groups on a visual analog scale (VAS) at the start. The pain was scored again on the VAS at 30 minutes, 1 hour, and 4 hours after the start of the treatment and at IV urography. Side effects, as well as the need for rescue medication, were registered. RESULTS: Both tramadol groups scored significantly better after 60 and 240 minutes and during IV urography (P < 0.005). There was a significant decrease in VAS in group B after 30 minutes. The tramadol groups needed significantly less rescue medication (P = 0.001). There was no significant difference in the reported side effects. The combination spasmolytic- tramadol drip scored the best, although the difference was not statistically significant. CONCLUSION:
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Authors | Luc J M Mortelmans, Didier Desruelles, Joost A Baert, K Robert Hente, Geert G Tailly |
Journal | Journal of endourology
(J Endourol)
Vol. 20
Issue 12
Pg. 1010-5
(Dec 2006)
ISSN: 0892-7790 [Print] United States |
PMID | 17206893
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Colic
(drug therapy)
- Humans
- Infusions, Intravenous
- Kidney Diseases
(drug therapy)
- Surveys and Questionnaires
- Time Factors
- Tramadol
(administration & dosage, therapeutic use)
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