VAB-6 and cisplatin-cyclophosphamide combinations in the treatment of metastatic seminoma patients: the U.S.S.R. experience.

Abstract

In a non-randomized study the treatment results of 59 patients with disseminated seminoma were evaluated: 21 patients were treated with a VAB-6 combination and 38 with a CP (cyclophosphamide and cisplatin) combination. After VAB-6 CR was observed in 8 patients and 6 achieved CR with additional treatment: 1 with chemotherapy (PVB) and 5 with radiotherapy (RT). The final CR rate was 67%. At a median follow-up of 38 (11-70) months 15 (71%) are alive, and 11 of them (52%) are NED; 6 have died. Of the 38 patients treated with CP alone only 18 achieved CR and 9 had a CR after additional RT and 1 chemotherapy (VAB-6), the overall CR rate was 72%. The median follow-up is 24 (4-55) months, 28 (74%) are alive, 24 (66%) are currently NED, and 9 have died. Both regimens were well tolerated, the main toxicity being leukopenia: 48% (WHO grade 111-1V-5%) for VAB-6, and 59% (13%) for CP. Hearing loss was registered in 8 patients receiving CP and in 2 receiving VAB-6. There were no fatal toxicities. Thus, VAB-6 and CP regimens seem to have compatible and high activity in disseminated seminoma.

• Authors: S A Tjulandin, A V Khlebnov, R J Nasirova, Z P Mikhina, G V Molchanov, V N Sholokhov, V A Sokolov, N A Vetrova, A M Garin
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 2 Issue 9 Pg. 667-72 (Oct 1991) ISSN: 0923-7534 [Print] England
• PMID: 1720656 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Bleomycin
• Dactinomycin
• Vinblastine
• Cyclophosphamide
• Cisplatin

Topics

• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Chi-Square Distribution
• Cisplatin (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Dactinomycin (administration & dosage)
• Dysgerminoma (drug therapy, mortality, pathology)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Neoplasm Metastasis
• Prognosis
• Remission Induction
• Survival Rate
• Testicular Neoplasms (drug therapy, mortality, pathology)
• USSR
• Vinblastine (administration & dosage)