| Abstract | OBJECTIVE: To study the prevalence of celiac disease among blood donor volunteers based on screening by IgA antitissue transglutaminase antibody, followed by a confirmatory small intestine biopsy. METHODS: The transversal study involved 3000 potential blood donors, residing in the city of Sao Paulo, Brazil. The participants were gender divided into 1500 men and 1500 women, with an average age 34.4+/-10.8 years, and included blood donor volunteers who could be turned down owing to anemia. All participants answered a questionnaire concerning the presence of diarrhea, constipation or abdominal pain during the 3 months before the study. Each participant with human recombinant IgA antitissue transglutaminase antibody level above 10 U/ml was invited to undergo a small intestine biopsy by means of an upper gastrointestinal endoscopy. The presence of villous atrophy and a positive antibody test were suggestive of possible celiac disease. RESULTS: Antitissue transglutaminase antibody was positive in 1.5% (45/3000) of the study population. Among the antibody-positive group, 21 (46.6%) agreed to have a biopsy performed, and within them the histological pattern of villous atrophy was confirmed in 66.7% (14/21). Consequently, the suggestive prevalence of celiac disease was at the minimum, one per 214 of the potential blood donor volunteers. A significant association was found between celiac disease and the symptoms of diarrhea, constipation and abdominal pain. CONCLUSIONS: The prevalence of celiac disease in Sao Paulo city is high and comparable to that observed in European countries. It is possible that in Brazil the prevalence of this disease had previously been underestimated. |
| Authors | Ricardo P Oliveira, Vera L Sdepanian, José A Barreto, Afonso J P Cortez, Fabrício O Carvalho, José O Bordin, Maria Angélica de Camargo Soares, Francy Reis da Silva Patrício, Elisabete Kawakami, Mauro Batista de Morais, Ulysses Fagundes-Neto
(Affiliation: Division of Pediatric Gastroenterology, Federal University of Sao Paulo, Paulista School of Medicine, Sao Paulo, Brazil.)
|
| Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 19
Issue 1
Pg. 43-9
(Jan 2007)
ISSN: 0954-691X England |
| PMID | 17206076
(Publication Type: Journal Article)
|
| Chemical References |
- Autoantibodies
- Biological Markers
- Immunoglobulin A
- transglutaminase 2
- Transglutaminases
- GTP-Binding Proteins
|
| Topics |
- Adult
- Autoantibodies
(blood)
- Biological Markers
(blood)
- Biopsy
- Blood Donors
(statistics & numerical data)
- Body Constitution
- Brazil
(epidemiology)
- Celiac Disease
(diagnosis, epidemiology, pathology)
- Female
- GTP-Binding Proteins
(immunology)
- Humans
- Immunoglobulin A
(blood)
- Intestinal Mucosa
(pathology)
- Intestine, Small
(pathology)
- Male
- Middle Aged
- Nutritional Status
- Prevalence
- Transglutaminases
(immunology)
|
