Abstract | OBJECTIVES: DESIGN: Prospective, controlled animal study. SETTING: Research laboratory of a university. SUBJECTS: Male Wistar rats weighing 300+/-20 g. INTERVENTIONS: Separate groups of rats were injected with alpha-naphtylthiourea to produce mild permeability pulmonary edema. They were then given 0, 7 (low), 13 (moderate), or 20 mL/kg (near functional residual capacity) perflubron doses and mechanically ventilated with a large (33 mL/kg) tidal volume for 15 mins. MEASUREMENTS AND MAIN RESULTS: 125I-albumin distribution space was used to assess lung microvascular permeability. Quasi-static respiratory system pressure-volume curves were analyzed. Administration of low and moderate perflubron doses significantly improved respiratory mechanics and reduced the ventilator-induced permeability alterations to the level observed in rats that were not ventilated. By contrast, a perflubron dose that was near functional residual capacity increased end-inspiratory plateau pressure and aggravated the permeability alterations due to high tidal volume ventilation. CONCLUSIONS: Near functional residual capacity but not low perflubron dose worsens ventilation-induced lung injury of preinjured lungs. This may provide some explanation for the negative results of the recent clinical trials, and it stresses the importance of the amount of perflubron used for partial liquid ventilation.
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Authors | Jean-Damien Ricard, Franck Iserin, Didier Dreyfuss, Georges Saumon |
Journal | Critical care medicine
(Crit Care Med)
Vol. 35
Issue 2
Pg. 561-7
(Feb 2007)
ISSN: 0090-3493 [Print] United States |
PMID | 17205026
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fluorocarbons
- Hydrocarbons, Brominated
- perflubron
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Topics |
- Animals
- Fluorocarbons
(administration & dosage)
- Hydrocarbons, Brominated
- Liquid Ventilation
(adverse effects)
- Male
- Rats
- Rats, Wistar
- Respiratory Distress Syndrome
(physiopathology, therapy)
- Respiratory Mechanics
(drug effects)
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