The efficacy of adipokines and indices of metabolic syndrome as predictors of severe obesity-related hepatic steatosis.

Abstract

The aim of this study was to investigate adiponectin, leptin, and metabolic syndrome as predictors of the severity of obesity-related steatosis. By ultrasonography steatosis-positive (cases) subjects (n = 141) were compared with controls (n = 111). Demographic and anthropometric data and serum concentrations of adiponectin, leptin, and insulin were measured. The impact of several criteria of metabolic syndrome, serum adiponectin concentrations, and serum leptin concentrations were tested using a multivariate logistic regression analysis. The frequency of metabolic syndrome was higher in cases (44.0% versus 9.2%; P < .0001). Cases were older and had higher insulin resistance, waist circumference, and lower concentrations of adiponectin (all P < .001). The upper adiponectin quartile was associated with a lesser grade of steatosis. Metabolic syndrome and adiponectin concentrations were independently associated with the probability of steatosis. In conclusion, adipokines and metabolic syndrome are useful indices for the prediction of the severity of obesity-related steatosis.

• Authors: Nahum Méndez-Sánchez, Norberto C Chávez-Tapia, Roberto Medina-Santillán, Antonio R Villa, Karla Sánchez-Lara, Guadalupe Ponciano-Rodríguez, Martha H Ramos, Misael Uribe
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 51 Issue 10 Pg. 1716-22 (Oct 2006) ISSN: 0163-2116 [Print] United States
• PMID: 17203555 (Publication Type: Journal Article)

Chemical References

• Adiponectin
• Leptin

Topics

• Adiponectin (blood)
• Adult
• Case-Control Studies
• Cross-Sectional Studies
• Fatty Liver (blood, diagnostic imaging, etiology)
• Female
• Humans
• Leptin (blood)
• Logistic Models
• Male
• Metabolic Syndrome (blood, complications, diagnostic imaging)
• Middle Aged
• Obesity (blood, complications, diagnostic imaging)
• Severity of Illness Index
• Ultrasonography