Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including angiotensinogen (AGT), cadherin 1 (CDH1), cyclooxygenase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n=1,095) recruited from the Korean population. In addition, three polymorphisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis controlling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A allele (MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was significantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P=0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area.

• Authors: Byung Lae Park, Yoon Jun Kim, Hyun Sub Cheong, Lyoung Hyo Kim, Yoo Hyun Choi, Hyo-Suk Lee, Hyoung Doo Shin
• Journal: Experimental & molecular medicine (Exp Mol Med) Vol. 38 Issue 6 Pg. 694-702 (Dec 31 2006) ISSN: 1226-3613 [Print] United States
• PMID: 17202846 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chemokine CCL2

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Hepatocellular (epidemiology, etiology, genetics, virology)
• Chemokine CCL2 (genetics)
• Female
• Haplotypes (genetics)
• Hepatitis B (complications, genetics, therapy, virology)
• Hepatitis B virus (physiology)
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• Promoter Regions, Genetic (genetics)