Effects of edaravone on singlet oxygen released from activated human neutrophils.

Abstract

The effects of edaravone, a curative agent for acute brain infarction, on singlet oxygen ((1)O2) released from activated human neutrophils were examined, and the effects were compared to those of histidine, a (1)O2 singlet oxygen scavenger. The neutrophils, stimulated with opsonized zymosan, released (1)O2 that was detected by chemiluminescence using a (1)O2 specific probe, trans-1-(2'-methoxyvinyl)pyrene. Edaravone dose-dependently suppressed the (1)O2 release with an IC(50) of approximately 0.3 microM, while the IC(50) of histidine was approximately 1 mM. This (1)O2 scavenging activity of edaravone might be involved in its curative effects on acute brain infarction.

• Authors: Piyanart Sommani, Toshiyuki Arai, Kouhei Yamashita, Takashi Miyoshi, Hiroko Mori, Masataka Sasada, Keisuke Makino
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 103 Issue 1 Pg. 117-20 (Jan 2007) ISSN: 1347-8613 [Print] Japan
• PMID: 17202745 (Publication Type: Journal Article)

Chemical References

• Free Radical Scavengers
• Singlet Oxygen
• Histidine
• Edaravone
• Antipyrine

Topics

• Adult
• Antipyrine (analogs & derivatives, pharmacology)
• Dose-Response Relationship, Drug
• Edaravone
• Free Radical Scavengers (pharmacology)
• Histidine (pharmacology)
• Humans
• Luminescent Measurements
• Neutrophil Activation
• Neutrophils (drug effects, metabolism)
• Singlet Oxygen (metabolism)