Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats.

Abstract

The present study was designed to investigate the antihyperglycemic effect of Umbelliferone (UMB) in normal and streptozotocin (STZ)-diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 180-200 g, by administration of STZ (40 mg/kg of body weight) intraperitoneally. Diabetic rats showed an increase in levels of blood glucose and glycosylated hemoglobin (HbA(1c)) and activities of gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-bisphosphatase, and a decrease in levels of plasma insulin, hemoglobin (Hb), and liver glycogen and activities of glucokinase and glucose-6-phosphate dehydrogenase. Intraperitoneal administration of UMB (10, 20, and 30 mg/kg of body weight) and glibenclamide (600 micro g/kg of body weight) in 10% dimethyl sulfoxide dissolved in water, for 45 days, produced significantly decreased levels of blood glucose and HbA(1c) and activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase, while elevating levels of plasma insulin, Hb, and liver glycogen and activities of glucokinase and glucose-6-phosphate dehydrogenase to near normal levels in STZ-diabetic rats when compared with normal control rats. Normal rats treated with UMB (30 mg/kg of body weight) also showed a significant effect on glycemic control. Thus, our results show that UMB at 30 mg/kg of body weight possesses a promising antihyperglycemic effect that is comparable with glibenclamide.

• Authors: B Ramesh, K V Pugalendi
• Journal: Journal of medicinal food (J Med Food) Vol. 9 Issue 4 Pg. 562-6 ( 2006) ISSN: 1096-620X [Print] United States
• PMID: 17201645 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Hemoglobins
• Hypoglycemic Agents
• Insulin
• Umbelliferones
• 7-hydroxycoumarin
• Glycogen
• Glucosephosphate Dehydrogenase
• Glucokinase
• Fructose-Bisphosphatase
• Glucose-6-Phosphatase
• Glyburide

Topics

• Animals
• Blood Glucose (analysis)
• Diabetes Mellitus, Experimental (blood, drug therapy, urine)
• Fructose-Bisphosphatase (metabolism)
• Glucokinase (metabolism)
• Glucose-6-Phosphatase (metabolism)
• Glucosephosphate Dehydrogenase (metabolism)
• Glyburide (administration & dosage)
• Glycated Hemoglobin (analysis)
• Glycogen (analysis)
• Glycosuria (drug therapy)
• Hemoglobins (analysis)
• Hypoglycemic Agents (therapeutic use)
• Insulin (blood)
• Kidney (enzymology)
• Liver (chemistry, enzymology)
• Male
• Rats
• Rats, Wistar
• Umbelliferones (administration & dosage, therapeutic use)